Diagnostic value of carbohydrate antigen 72-4 combined with carbohydrate antigen 15.3 in ovarian cancer, cervical cancer and endometrial cancer.

This study was designed to explore the value of carbohydrate antigen 72-4 (CA72-4) combined with carbohydrate antigen 15-3 (CA153) in diagnosing gynecologic malignancies. 64 patients with ovarian cancer admitted to our hospital from February 2014 to February 2016 comprised the group A; 52 cases of cervical cancer were regarded as group B; 46 cases of endometrial cancer comprised the group C; and 150 cases of healthy women were considered as a control group. The CA72-4 and CA15.3 levels in serum of each group were detected, and receiver operating characteristics (ROC) curve was used to analyze the diagnostic value of CA72-4 and CA15.3 in ovarian, cervical, as well as in endometrial cancer. CA72-4 and CA15.3 increased dramatically in cancer patients (p<0.001). CA15.3 in group C was higher than in groups A and B (p<0.05). Joint diagnosis of the two had good sensitivity, specificity and area under the curve (AUC) for ovarian, cervical as well as for endometrial cancer (p<0.001). CA72-4 and CA15.3 were closely related to the occurrence of gynecologic malignancies (p<0.001). The results of follow-up revealed that CA72-4 had a higher value in predicting the death of ovarian cancer patients within 3 years, while CA15.3 had a better effect in predicting the death of ovarian and cervical cancer (p<0.05). CA72-4 and CA15.3 were dramatically higher in ovarian, cervical and endometrial cancer among gynecologic malignancies. Joint detection of the two had better diagnostic value for ovarian and cervical cancer.

Citation

Meiling Li, Xiaojuan Men, Xiujuan Zhang. Diagnostic value of carbohydrate antigen 72-4 combined with carbohydrate antigen 15.3 in ovarian cancer, cervical cancer and endometrial cancer. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2020 Jul-Aug;25(4):1918-1927

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PMID: 33099933

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