A review on development of MUC1-based cancer vaccine.

Mucin 1 (MUC1) is a transmembrane mucin glycoprotein expressed on the surface of almost all epithelial cells. Aberrantly glycosylated MUC1 is associated with cellular transformation from a normal to malignant phenotype in human cancers. Therefore, MUC1 is the major target for the design and development of cancer vaccines. MUC1-based cancer vaccines are a promising strategy for preventing cancer progression and metastasis. This review summarizes the most significant milestones achieved to date in the development of different MUC-1-based vaccine approaches in clinical trials. Further, it provides perspectives for future research that may promote clinical advances in infection-associated cancers. Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.

Citation

Tong Gao, Qianhong Cen, Han Lei. A review on development of MUC1-based cancer vaccine. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Dec;132:110888

Mesh Tags

Substances

PMID: 33113416

search → result