Gastric Hyperplastic Polyps after Argon Plasma Coagulation for Gastric Antral Vascular Ectasia in Patients with Liver Cirrhosis: A Case Suggesting the "Gastrin Link Theory".

Ken Nishino, Miwa Kawanaka, Mitsuhiko Suehiro, Naoko Yoshioka, Jun Nakamura, Noriyo Urata, Tomohiro Tanigawa, Takako Sasai, Takahito Oka, Yasumasa Monobe, Yoshiaki Saji, Hirofumi Kawamoto, Ken Haruma

Internal medicine (Tokyo, Japan) 2021 Apr 01

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We herein report a case of gastric hyperplastic polyps after argon plasma coagulation (APC) for gastric antral vascular ectasia (GAVE) in the antrum of a 65-year-old man with liver cirrhosis and hypergastrinemia induced by long-term proton pump inhibitor (PPI) use. Two years after APC therapy, endoscopy demonstrated multiple gastric polyps in the antrum and angle. A gastric polyp biopsy indicated foveolar epithelium hyperplasia, which was diagnosed as gastric hyperplastic polyps. One year after switching to an H2 blocker antagonist, endoscopy revealed that the polyps and GAVE had disappeared, with normal gastrin levels suggesting that PPI-induced hypergastrinemia had caused gastric hyperplastic polyps after APC therapy, and the polyps had disappeared after discontinuing PPIs.

Citation

Ken Nishino, Miwa Kawanaka, Mitsuhiko Suehiro, Naoko Yoshioka, Jun Nakamura, Noriyo Urata, Tomohiro Tanigawa, Takako Sasai, Takahito Oka, Yasumasa Monobe, Yoshiaki Saji, Hirofumi Kawamoto, Ken Haruma. Gastric Hyperplastic Polyps after Argon Plasma Coagulation for Gastric Antral Vascular Ectasia in Patients with Liver Cirrhosis: A Case Suggesting the "Gastrin Link Theory". Internal medicine (Tokyo, Japan). 2021 Apr 01;60(7):1019-1025