Indolyl- and Pyrrolylazine Derivatives Cause the Accumulation of Heat Shock Protein Hsp70 in Sh-Sy5Y Human Neuroblastoma Cells.

V F Lazarev, E R Mikhaylova, M A Mikeladze, M A Trestsova, I A Utepova, O N Chupakhin, B A Margulis, I V Guzhova

Doklady. Biochemistry and biophysics 2020 Sep

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The heat shock protein Hsp70 is involved in cell defense from various types of stress, including the proteotoxic stress, which occurs during the development of many neurodegenerative diseases. This work presents data on the detection of small molecules, derivatives of indolyl- and pyrrolylazines, which can activate the synthesis of Hsp70 and cause its accumulation in the cell. The toxicity level of the new Hsp70 synthesis inducers was evaluated, and the safety of these compounds was demonstrated in experiments on SH-SY5Y neuroblastoma cell line. Derivatives of indolyl- and pyrrolylazines presented in this work can be potential therapeutic agents in models of neurodegenerative diseases that should be studied in more detail.

Citation

V F Lazarev, E R Mikhaylova, M A Mikeladze, M A Trestsova, I A Utepova, O N Chupakhin, B A Margulis, I V Guzhova. Indolyl- and Pyrrolylazine Derivatives Cause the Accumulation of Heat Shock Protein Hsp70 in Sh-Sy5Y Human Neuroblastoma Cells. Doklady. Biochemistry and biophysics. 2020 Sep;494(1):248-251