A modular template for the design of thiol-triggered sensors and prodrugs.

A unique reaction between thiols (RSH) and alkyl sulfonylbenzothiazole was discovered. This reaction was specific for thiols and produced a sulfinic acid (RSO2H) as the intermediate, which further triggered an intramolecular cyclization to release a -OH containing payload. This reaction was used to develop thiol-triggered fluorescent sensors and prodrugs. The modular design of this template provides tunability of the release profiles of the payloads. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Jessica Renee Knight, Yingying Wang, Shi Xu, Wei Chen, Clifford E Berkman, Ming Xian. A modular template for the design of thiol-triggered sensors and prodrugs. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Feb 15;247:119072

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PMID: 33128946

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