Jessica Renee Knight, Yingying Wang, Shi Xu, Wei Chen, Clifford E Berkman, Ming Xian
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2021 Feb 15A unique reaction between thiols (RSH) and alkyl sulfonylbenzothiazole was discovered. This reaction was specific for thiols and produced a sulfinic acid (RSO2H) as the intermediate, which further triggered an intramolecular cyclization to release a -OH containing payload. This reaction was used to develop thiol-triggered fluorescent sensors and prodrugs. The modular design of this template provides tunability of the release profiles of the payloads. Copyright © 2020 Elsevier B.V. All rights reserved.
Jessica Renee Knight, Yingying Wang, Shi Xu, Wei Chen, Clifford E Berkman, Ming Xian. A modular template for the design of thiol-triggered sensors and prodrugs. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Feb 15;247:119072
PMID: 33128946
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