Correlation Engine 2.0
Clear Search sequence regions

  • 4 hydroxycoumarins (2)
  • cyclic (1)
  • female (1)
  • half life (3)
  • indans (2)
  • isomers (1)
  • liver (1)
  • rodent control (1)
  • rodenticides (4)
  • stereoisomers (1)
  • toxin (1)
  • vole (5)
  • Sizes of these terms reflect their relevance to your search.

    Cyclic water vole population explosions can be controlled in some European countries with anticoagulant rodenticides leading sometimes to wildlife poisonings due to the toxin's tissue persistence. Here, we analyzed the pharmacokinetics of rodenticide residues in voles and we explored potential ways of improving the mass application of these agents based on the concept of stereoisomers. We demonstrated the dramatic persistence of bromadiolone in vole tissues with a hepatic half-life of about 10-30 days, while the tissue persistence of chlorophacinone is rather short with a hepatic half-life of about one day. The dramatic persistence of bromadiolone is due to the trans-isomer group (the major compound in bromadiolone), while the cis-isomer group has a short half-life. Because of resistance to chlorophacinone, the cis-bromadiolone isomers may constitute an excellent compromise between efficacy and ecotoxicological risk to control voles. A mathematical model is proposed to favor the development of baits mixed with cis-isomer groups. Copyright © 2020 Elsevier B.V. All rights reserved.


    Rami Abi Khalil, Brigitte Barbier, Antoine Rached, Etienne Benoit, Adrien Pinot, Virginie Lattard. Water vole management - Could anticoagulant rodenticides stereochemistry mitigate the ecotoxicity issues associated to their use? Environmental toxicology and pharmacology. 2021 Jan;81:103536

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33130091

    View Full Text