Development of a high-strength Zn-Mn-Mg alloy for ligament reconstruction fixation.

Jiang Sun, Xin Zhang, Zhang-Zhi Shi, Xi-Xian Gao, Hui-Yan Li, Feng-Yuan Zhao, Jian-Quan Wang, Lu-Ning Wang

Acta biomaterialia 2021 Jan 01

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Although various biodegradable materials have been investigated for ligament reconstruction fixation in the past decades, only few of them possess a combination of high mechanical properties, appropriate degradation rate, good biocompatibility, and osteogenic effect, thus limiting their clinical applications. A high-strength Zn-0.8Mn-0.4Mg alloy (i.e., Zn08Mn04Mg) with yield strength of 317 MPa was developed to address this issue. The alloy showed good biocompatibility and promising osteogenic effect in vitro. The degradation effects of Zn08Mn04Mg interference screws on the interface between soft tissue and bone were investigated in anterior cruciate ligament (ACL) reconstruction in rabbits. Compared to Ti6Al4V, the Zn alloy screws significantly accelerated the formation of new bone and further induced partial tendon mineralization, which promoted tendon-bone integration. The newly developed screws are believed to facilitate early joint function recovery and rehabilitation training and also avoid screw breakage during insertion, thereby contributing to an extensive clinical prospect. Copyright © 2020. Published by Elsevier Ltd.

Citation

Jiang Sun, Xin Zhang, Zhang-Zhi Shi, Xi-Xian Gao, Hui-Yan Li, Feng-Yuan Zhao, Jian-Quan Wang, Lu-Ning Wang. Development of a high-strength Zn-Mn-Mg alloy for ligament reconstruction fixation. Acta biomaterialia. 2021 Jan 01;119:485-498