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Endocrine late effects, including reproductive disorders and secondary thyroid cancer, have been reported in up to 50 %childhood cancer survivors (CCS) more than 5 years after treatment. Most endocrine disorders are amenable to treatment; awareness of symptoms is therefore of great importance. Recognition of these symptoms may be delayed however because many are nonspecific. Timely treatment of endocrine disorders improves quality of life in CCS and prevents possible consequences, such as short stature, bone and cardiovascular disorders, and depression. At-risk CCS must therefore be regularly and systematically monitored. This article provides a summary of the most commonly reported endocrine late effects in CCS. Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.


Hanneke M van Santen, Wassim Chemaitilly, Lillian R Meacham, Emily S Tonorezos, Sogol Mostoufi-Moab. Endocrine Health in Childhood Cancer Survivors. Pediatric clinics of North America. 2020 Dec;67(6):1171-1186

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PMID: 33131540

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