Nanomolar level detection of non-steroidal antiandrogen drug flutamide based on ZnMn2O4 nanoparticles decorated porous reduced graphene oxide nanocomposite electrode.

Krishnan Venkatesh, Balamurugan Muthukutty, Shen-Ming Chen, Chelladurai Karuppiah, Baishnisha Amanulla, Chun-Chen Yang, Sayee Kannan Ramaraj

Journal of hazardous materials 2021 Mar 05

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Flutamide is a non-steroidal antiandrogen drug and widely used in the treatment of prostatic carcinoma. Nevertheless, the excessive intake and improper disposal could affect the living organisms. In this work, we have synthesized a new nanocomposite based on ZnMn2O4 nanoparticles and porous reduced graphene oxide nanosheets (ZnMn2O4-PGO) for the electrocatalytic detection of flutamide (FLU) drug. The crystallinity and morphological properties of ZnMn2O4-PGO composite examined by different characterization techniques such as X-ray diffraction, Raman spectroscopy and so on. The fabricated ZnMn2O4-PGO nanocomposite modified electrode exhibited superior electrocatalytic performance to FLU drug in an optimized pH electrolyte. Fascinatingly, the electrode received a wide linear range (0.05-3.5 µM) with limit of detection of 8 nM. Besides, the developed ZnMn2O4-PGO nanocomposite electrode showed good sensitivity 1.05 µAµM-1 cm-2 and excellent selectivity for FLU detection in presence of various interfering species. A developed disposable electrode was scrutinized to determine FLU level in human urine samples by spiking method and the results achieved good recoveries in real sample analysis. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Krishnan Venkatesh, Balamurugan Muthukutty, Shen-Ming Chen, Chelladurai Karuppiah, Baishnisha Amanulla, Chun-Chen Yang, Sayee Kannan Ramaraj. Nanomolar level detection of non-steroidal antiandrogen drug flutamide based on ZnMn2O4 nanoparticles decorated porous reduced graphene oxide nanocomposite electrode. Journal of hazardous materials. 2021 Mar 05;405:124096