Clear Search sequence regions


  • cell hypoxia (2)
  • factor (4)
  • gene (1)
  • HIF 1α (1)
  • HIF- 1 (12)
  • humans (2)
  • hypoxia (1)
  • impairs (1)
  • life cycle (1)
  • regulates (1)
  • Sizes of these terms reflect their relevance to your search.

    Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs the formation of an active heterodimer in the nucleus that otherwise regulates the expression of numerous genes. Importantly, HIF-1 participates in both cancer and infectious diseases unveiling new therapeutic targets for those ailments. Here, we discuss aspects related to the activation of HIF-1, the effects of this transcription factor over immune system components, as well as the involvement of HIF-1 activity in response to viral infections in humans. Although HIF-1 is currently being assessed in numerous clinical settings as a potential therapy for different diseases, up to date, there are no clinical studies evaluating the pharmacological modulation of this transcription factor as a possible new antiviral treatment. However, based on the available evidence, clinical trials targeting this molecule are likely to occur soon. In this review we discuss the role of HIF-1 in viral immunity, the modulation of HIF-1 by different types of viruses, as well as the effects of HIF-1 over their life cycle and the potential use of HIF-1 as a new target for the treatment of viral infections.

    Citation

    Antonia Reyes, Nicolás Corrales, Nicolás M S Gálvez, Susan M Bueno, Alexis M Kalergis, Pablo A González. Contribution of hypoxia inducible factor-1 during viral infections. Virulence. 2020 Dec;11(1):1482-1500

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 33135539

    View Full Text