Biomarkers of treatment success in fully sensitive pulmonary tuberculosis patients: a multicenter longitudinal study.

Vladyslav Nikolayevskyy, Yanina Balabanova, Irina Kontsevaya, Olga Ignatyeva, Girts Skenders, Edita Vasiliauskiene, David van Bockel, Francis Drobniewski

Biomarkers in medicine 2020 Oct

filter terms:

Aim: Novel biomarkers that are able to accurately monitor tuberculosis (TB) treatment effectiveness are needed to adjust therapy and identify a need for a regimen change. Materials & methods: In our study, conducted on a cohort comprising 100 pulmonary TB patients, we analyzed the role of plasma cytokines and Toll-like receptors expression as biomarkers of treatment response. Results: Changes in toll-interacting protein (TOLLIP) and lymphocyte antigen 96 (LY96) gene expression as well as nine cytokine levels over the first 2 months were significantly associated with successful treatment outcome. Successful treatment was associated with higher serum concentration of Toll-like receptor-2. Conclusion: Our results suggest that differential expression of specific effector molecules and dynamics of selected cytokines may help to identify those responding to TB treatment early.

Citation

Vladyslav Nikolayevskyy, Yanina Balabanova, Irina Kontsevaya, Olga Ignatyeva, Girts Skenders, Edita Vasiliauskiene, David van Bockel, Francis Drobniewski. Biomarkers of treatment success in fully sensitive pulmonary tuberculosis patients: a multicenter longitudinal study. Biomarkers in medicine. 2020 Oct;14(15):1439-1452