COVID-19 in Lung Transplant Recipients.
Jonathan Messika, Philippine Eloy, Antoine Roux, Sandrine Hirschi, Ana Nieves, Jérôme Le Pavec, Agathe Sénéchal, Christel Saint Raymond, Nicolas Carlier, Xavier Demant, Aurélie Le Borgne, Adrien Tissot, Marie-Pierre Debray, Laurence Beaumont, Benjamin Renaud-Picard, Martine Reynaud-Gaubert, Jean-François Mornex, Loïc Falque, Véronique Boussaud, Jacques Jougon, Sacha Mussot, Hervé Mal, French Group of Lung Transplantation
Transplantation 2021 Jan 01A concern about the susceptibility of immunocompromised patients to the worldwide pandemic of coronavirus disease 2019 (COVID-19) has been raised. We aimed at describing COVID-19 infections in the French cohort of lung transplant (LT) patients. Multicenter nationwide cohort study of all LT recipients with COVID-19 diagnosed from March 1 to May 19, 2020. Recipient main characteristics and their management were retrieved. Hospitalization characteristics, occurrence of complications and survival were analyzed. Thirty-five LT patients with a COVID-19 infection were included. Median age was 50.4 (40.6-62.9) years, 16 (45.7%) were female, and 80% were double-LT recipients. Infection was community-acquired in 25 (71.4%). Thirty-one (88.6%) required hospitalization, including 13 (41.9%) in the intensive care unit. The main symptoms of COVID-19 were fever, cough, and diarrhea, present in 71.4%, 54.3%, and 31.4% of cases, respectively. Extension of pneumonia on chest CT was moderate to severe in 51.4% of cases. Among the 13 critically ill patients, 7 (53.9%) received invasive mechanical ventilation. Thrombotic events occurred in 4 patients. Overall survival rate was 85.7% after a median follow-up of 50 days (41.0-56.5). Four of 5 nonsurvivors had had bronchial complications or intensification of immunosuppression in the previous weeks. On univariate analysis, overweight was significantly associated with risk of death (odds ratio, 16.0; 95% confidence interval, 1.5-170.6; P = 0.02). For the 35 LT recipients with COVID-19, the presentation was severe, requiring hospitalization in most cases, with a survival rate of 85.7%. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Citation
Jonathan Messika, Philippine Eloy, Antoine Roux, Sandrine Hirschi, Ana Nieves, Jérôme Le Pavec, Agathe Sénéchal, Christel Saint Raymond, Nicolas Carlier, Xavier Demant, Aurélie Le Borgne, Adrien Tissot, Marie-Pierre Debray, Laurence Beaumont, Benjamin Renaud-Picard, Martine Reynaud-Gaubert, Jean-François Mornex, Loïc Falque, Véronique Boussaud, Jacques Jougon, Sacha Mussot, Hervé Mal, French Group of Lung Transplantation. COVID-19 in Lung Transplant Recipients. Transplantation. 2021 Jan 01;105(1):177-186
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PMID: 33141808
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