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Bacterial cellulose (BC) is used in various fields for its unique physical properties, but does not have the antimicrobial properties needed for the food and biomedical industries. Co-culture fermentation is a method commonly used in biotechnology to address high costs. A nisin-containing BC film (BC-N) was obtained by co-cultivating the BC-producing strain Enterobacter sp. FY-07 with the nisin-producing strain Lactococcus lactis N8. The physical properties of BC-N were similar those of BC, but the BC-N film had a specific strong inhibitory effect on Gram-positive bacteria. The antibacterial mechanism of BC-N was pore formation, but the obtained BC-N film had no significant impact on mammalian cell viability. This study provides a low-cost, facile and efficient technique to confer BC with antimicrobial properties. This strategy can be applied to introduce other functions into BC, and develop applications for BC polymers. Copyright © 2020. Published by Elsevier Ltd.


Ge Gao, Huiqiang Fan, Yibo Zhang, Yiyan Cao, Te Li, Wanjin Qiao, Mengmeng Wu, Ting Ma, Guoqiang Li. Production of nisin-containing bacterial cellulose nanomaterials with antimicrobial properties through co-culturing Enterobacter sp. FY-07 and Lactococcus lactis N8. Carbohydrate polymers. 2021 Jan 01;251:117131

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PMID: 33142662

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