Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan.

Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among Taiwanese. One hundred and ninety-eight asthma patients and 453 non-asthmatic subjects were determined with respect to their MMP2 -1306 (rs243845) and -735 (rs2285053) genotypes. CT and TT at MMP2 rs243845 are 17.7% and 1.5% among asthma cases, whereas their presence in healthy subjects is at 28.1% and 2.4%, respectively (p for trend=0.0118). In detail, the CT genotype in MMP2 rs243845 was associated with a decreased asthma risk [adjusted odds ratio (OR)=0.57, 95% confidence interval (CI)=0.37-0.78, p=0.0040], and the T allele conferred a significantly lower asthma risk compared to the wild-type C allele (adjusted OR=0.55, 95%CI=0.43-0.77, p=0.0042). No significance was found for MMP2 rs2285053. The genotype of CT in MMP2 rs243845 may serve as a novel biomarker in determining susceptibility to asthma in Taiwan. Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Citation

Li-Hsiou Chen, Kuo-Liang Chiu, Te-Chun Hsia, Yen-Hsien Lee, Te-Chun Shen, Chia-Hsiang Li, Yi-Cheng Shen, Wen-Shin Chang, Chia-Wen Tsai, DA-Tian Bau. Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan. In vivo (Athens, Greece). 2020 Nov-Dec;34(6):3181-3186

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PMID: 33144422

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