A peptide-based aggregation-induced emission bioprobe for selective detection and photodynamic killing of Gram-negative bacteria.

Herein, we report a new bioprobe with aggregation-induced emission (AIE) characteristics by conjugation of a far-red/near-infrared emissive AIE luminogen and two polymyxinB peptides. Due to the strong binding effect between polymyxin B and the lipopolysaccharide in the cell wall of Gram-negative bacteria, the bioprobe can selectively visualize Gram-negative bacteria and effectively kill them via photodynamic treatment.

Citation

Pingping Bao, Cong Li, Hanlin Ou, Shenglu Ji, Yao Chen, Jing Gao, Xin Yue, Jing Shen, Dan Ding. A peptide-based aggregation-induced emission bioprobe for selective detection and photodynamic killing of Gram-negative bacteria. Biomaterials science. 2021 Jan 26;9(2):437-442

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PMID: 33146160

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