Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes.

Harvey J Kliman, Morgan R Firestein, Katherine M Hofmann, Kristin M Milano, Parker H Holzer, Lucy T Brink, Hein J Odendaal, William P Fifer

Placenta 2021 Jan 01

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We sought to examine placentas enriched for trophoblast inclusions (TIs) in order to characterize, quantify, and examine the interrelations between subtypes of TIs to better understand their underlying biology. We examined a cohort of 600 placentas from deliveries between 200 and 430 weeks of gestation. Forty-five percent of the placentas had at least one TI in the two slides examined. Four percent of the placentas had 10 or more TIs and two placentas had more than 70 TIs. Four distinct TI subtypes were observed: inclusionoids (early forming inclusions), inclusions, calcified inclusions, and calcified bodies. We suggest this reflects a developmental trajectory of TI maturation, the timing of which might be useful when comparing TI expression to clinical outcomes. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Harvey J Kliman, Morgan R Firestein, Katherine M Hofmann, Kristin M Milano, Parker H Holzer, Lucy T Brink, Hein J Odendaal, William P Fifer. Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes. Placenta. 2021 Jan 01;103:172-176