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Hematuria is one of the most common laboratory findings in nephrology practice. To date, there is no enough data regarding the clinical and histopathologic characteristics of primary glomerular disease (PGD) patients with hematuria in our country. Data were obtained from national multicenter (47 centers) data entered into the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database between May 2009 and June 2019. The data of all PGD patients over the age of 16 years who were diagnosed with renal biopsy and had hematuria data were included in the study. Demographic characteristics, laboratory and biopsy findings were also recorded. Data of 3394 PGD patients were included in the study. While 1699 (50.1%) patients had hematuria, 1695 (49.9%) patients did not have hematuria. Patients with hematuria had statistically higher systolic blood pressure, serum blood urea nitrogen, creatinine, albumin, levels and urine pyuria. However, these patients had statistically lower age, body mass index, presence of hypertension and diabetes, eGFR, 24-h proteinuria, serum total, HDL and LDL cholesterol, and C3 levels when compared with patients without hematuria. Hematuria was present 609 of 1733 patients (35.8%) among the patients presenting with nephrotic syndrome, while it was presented in 1090 of 1661 (64.2%) patients in non-nephrotics (p < 0.001). This is the first multicenter national report regarding the demographic and histopathologic data of PGD patients with or without hematuria. Hematuria, a feature of nephritic syndrome, was found at a higher than expected in the PGDs presenting with nephrotic syndrome in our national database.

Citation

Abdullah Sumnu, Kultigin Turkmen, Egemen Cebeci, Aydin Turkmen, Necmi Eren, Nurhan Seyahi, Aysegul Oruc, Fatih Dede, Ülver Derici, Taner Basturk, Garip Şahin, Murat Sipahioglu, Gulizar Manga Sahin, Erhan Tatar, Belda Dursun, Savas Sipahi, Mürvet Yılmaz, Gultekin Suleymanlar, Sena Ulu, Ozkan Gungor, Sim Kutlay, Zerrin Bicik Bahçebaşı, İdris Sahin, Ilhan Kurultak, Can Sevinc, Zulfikar Yilmaz, Rumeyza Turan Kazancioglu, Caner Cavdar, Ferhan Candan, Zeki Aydin, Deren Oygar, Bulent Gul, Bulent Altun, Saime Paydas, Sami Uzun, Zulal Istemihan, Metin Ergul, Mevlut Tamer Dincer, Mustafa Gullulu, Serhan Piskinpasa, Omer Faruk Akcay, Abdulkadir Unsal, Sumeyra Koyuncu, Mahmut Gok, Savas Ozturk. Characteristics of primary glomerular diseases patients with hematuria in Turkey: the data from TSN-GOLD Working Group. International urology and nephrology. 2021 May;53(5):945-954


PMID: 33155086

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