T cell factor 1: A master regulator of the T cell response in disease.

Giulia Escobar, Davide Mangani, Ana C Anderson

Science immunology 2020 Nov 06

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Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent role of TCF1 in peripheral T cells, particularly during disease-induced inflammatory states such as autoimmunity, cancer, and chronic infections. Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Citation

Giulia Escobar, Davide Mangani, Ana C Anderson. T cell factor 1: A master regulator of the T cell response in disease. Science immunology. 2020 Nov 06;5(53)