Correlation Engine 2.0
Clear Search sequence regions

  • behavior (2)
  • calcium (1)
  • cognitive (1)
  • hippocampus (2)
  • memory (5)
  • mice (1)
  • opsins (2)
  • photons (1)
  • reward (1)
  • spatial behavior (3)
  • Sizes of these terms reflect their relevance to your search.

    The hippocampus is crucial for spatial navigation and episodic memory formation. Hippocampal place cells exhibit spatially selective activity within an environment and have been proposed to form the neural basis of a cognitive map of space that supports these mnemonic functions. However, the direct influence of place cell activity on spatial navigation behavior has not yet been demonstrated. Using an 'all-optical' combination of simultaneous two-photon calcium imaging and two-photon optogenetics, we identified and selectively activated place cells that encoded behaviorally relevant locations in a virtual reality environment. Targeted stimulation of a small number of place cells was sufficient to bias the behavior of animals during a spatial memory task, providing causal evidence that hippocampal place cells actively support spatial navigation and memory. Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.


    Nick T M Robinson, Lucie A L Descamps, Lloyd E Russell, Moritz O Buchholz, Brendan A Bicknell, Georgy K Antonov, Joanna Y N Lau, Rebecca Nutbrown, Christoph Schmidt-Hieber, Michael Häusser. Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior. Cell. 2020 Dec 10;183(6):1586-1599.e10

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33159859

    View Full Text