Organoid model: A new hope for pancreatic cancer treatment?

Haidi Chen, Qifeng Zhuo, Zeng Ye, Xiaowu Xu, Shunrong Ji

Biochimica et biophysica acta. Reviews on cancer 2021 Jan

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Pancreatic cancer is a rapidly progressing disease with a poor prognosis. We still have many questions about the pathogenesis, early diagnosis and precise treatment of this disease. Organoids, a rapidly emerging technology, can simulate the characteristics of pancreatic tumors. Using the organoid model of pancreatic cancer, we can study and explore the characteristics of pancreatic cancer, thereby effectively guiding clinical practice and improving patient prognosis. This review introduces the development of organoids, comparisons of organoids with other preclinical models and the status of organoids in basic research and clinical applications for pancreatic cancer. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Haidi Chen, Qifeng Zhuo, Zeng Ye, Xiaowu Xu, Shunrong Ji. Organoid model: A new hope for pancreatic cancer treatment? Biochimica et biophysica acta. Reviews on cancer. 2021 Jan;1875(1):188466