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Different spectrophotometic quantitative analytical methods have been developed and applied for quantitative determination of lesinurad and allopurinol in their newly FDA approved pharmaceutical dosage form. lesinurad was quantitatively analyzed based on its unique UV spectra without any mathematical processing step. Direct quantitative analysis was done through its recorded zero-order absorption spectra at 290 nm without any contribution from allopurinol. On the other hand two processing mathematical spectrophotometric methods were applied to enable quantitative analysis of allopurinol through resolving of the recorded overlapping UV spectra between lesinurad and allopurinol. Ratio difference and ratio derivative spectra manipulated methods were enabled successful quantitative determination of allopurinol without any contribution from lesinurad. The described methods were successfully applied for the quantitative analysis of the two drugs in Duzallo ® pharmaceutical dosage form. Copyright © 2020 Elsevier B.V. All rights reserved.


Ahmed A Mohamed, Ahmed El-Olemy, Sherif Ramzy, Ahmed H Abdelazim, Mohamed K M Omar, Mohamed Shahin. Spectrophotometric determination of lesinurad and allopurinol in recently approved FDA pharmaceutical preparation. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Feb 15;247:119106

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PMID: 33160135

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