A review of pretreatment and analysis of macrolides in food (Update Since 2010).

Cong Hu, Yuan Zhang, Yu Zhou, Zhi-Fei Liu, Qiang Meng, Xue-Song Feng

Journal of chromatography. A 2020 Dec 20

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Macrolides are versatile broad-spectrum antibiotics whose activity stems from the presence of a macrolide ring. They are widely used in veterinary medicine to prevent and treat disease. However, because of their improper use and the absence of effective regulation, these compounds pose a threat to human health and the environment. Consequently, simple, quick, economical, and effective techniques are required to analyze macrolides in animal-derived foods, biological samples, and environmental samples. This paper presents a comprehensive overview of the pretreatment and analytical methods used for macrolides in various sample matrices, focusing on the developments since 2010. Pretreatment methods mainly include liquid-liquid extraction, solid-phase extraction, matrix solid-phase dispersion, and microextraction methods. Detection and quantification methods mainly include liquid chromatography (coupled to mass spectrometry or other detectors), electrochemical methods, capillary electrophoresis, and immunoassays. Furthermore, a comparison between the pros and cons of these methods and prospects for future developments are also discussed. Copyright © 2020. Published by Elsevier B.V.

Citation

Cong Hu, Yuan Zhang, Yu Zhou, Zhi-Fei Liu, Qiang Meng, Xue-Song Feng. A review of pretreatment and analysis of macrolides in food (Update Since 2010). Journal of chromatography. A. 2020 Dec 20;1634:461662