Two Cases of Autoimmune Neutropenia Complicated with Other Lineages of Autoimmune Cytopenia, Successfully Treated with Prednisolone.

Yoshiya Adachi, Yumi Yamazoe-Ishiguri, Satoshi Iwata, Atsushi Murase, Rika Kihara, Koichi Watamoto

Internal medicine (Tokyo, Japan) 2021 Apr 15

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Though adult-onset primary autoimmune pancytopenia (AIP) rarely follows a self-limited course, a standard treatment strategy has not yet been established. We herein report two cases, each involving primary autoimmune neutropenia complicated with autoimmune thrombocytopenia or Evans syndrome. They were refractory to granulocyte-colony stimulating factor, but all lineages of cytopenia promptly recovered with prednisolone (PSL). In case 1, PSL was tapered and discontinued six months after its initiation without AIP relapse. In case 2, PSL has been tapered for five months without relapse. To establish an optimal treatment strategy for AIP, it is necessary to accumulate more cases.

Citation

Yoshiya Adachi, Yumi Yamazoe-Ishiguri, Satoshi Iwata, Atsushi Murase, Rika Kihara, Koichi Watamoto. Two Cases of Autoimmune Neutropenia Complicated with Other Lineages of Autoimmune Cytopenia, Successfully Treated with Prednisolone. Internal medicine (Tokyo, Japan). 2021 Apr 15;60(8):1271-1277