Diffuse Intracerebral Hemorrhage in an Infant With a Novel Homozygous Variant Leading to Severe Protein C Deficiency.

Georgina Martin, Mary Ann Thomas, Xing-Chang Wei, Doan Le

Journal of pediatric hematology/oncology 2021 Aug 01

filter terms:

Protein C is a circulating anticoagulant that inhibits factor Va and VIIIa and promotes fibrinolysis. Compound heterozygous or homozygous variants in the Protein C gene (PROC) lead to severe deficiency of protein C and affected neonates typically present shortly after birth with purpura fulminans. We describe an infant who suffered a diffuse intracranial hemorrhage as a neonate and presented with purpura fulminans as an older infant which led to investigations that were consistent with severe protein C deficiency. We demonstrate subacute findings on neuroimaging and suggest this condition should be considered with neonatal presentations of bilateral intraparenchymal hemorrhage. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Georgina Martin, Mary Ann Thomas, Xing-Chang Wei, Doan Le. Diffuse Intracerebral Hemorrhage in an Infant With a Novel Homozygous Variant Leading to Severe Protein C Deficiency. Journal of pediatric hematology/oncology. 2021 Aug 01;43(6):e763-e765