Correlation Engine 2.0
Clear Search sequence regions

  • anhedonia (13)
  • humans (1)
  • reflect (1)
  • stress disorder (3)
  • suggests (1)
  • trauma (2)
  • Sizes of these terms reflect their relevance to your search.

    Anhedonic symptoms of posttraumatic stress disorder (PTSD) reflect deficits in reward processing that have significant functional consequences. Although recent evidence suggests that disrupted integrity of fronto-limbic circuitry is related to PTSD development, including anhedonic PTSD symptoms (posttrauma anhedonia [PTA]), little is known about potential structural biomarkers of long-term PTA as well as structural changes in fronto-limbic pathways associated with recovery from PTA over time. We investigated associations between white matter microstructure, gray matter volume, and PTA in 75 recently traumatized individuals, with a subset of participants (n = 35) completing follow-up assessment 12 months after trauma exposure. Deterministic tractography and voxel-based morphometry were used to assess changes in white and gray matter structure associated with changes in PTA. Reduced fractional anisotropy (FA) of the uncinate fasciculus at around the time of trauma predicted greater PTA at 12-months posttrauma. Further, increased FA of the fornix over time was associated with lower PTA between 1 and 12-months posttrauma. Increased gray matter volume of the ventromedial prefrontal cortex and precuneus over time was also associated with reduced PTA. The microstructure of the uncinate fasciculus, an amygdala-prefrontal white matter connection, may represent a biomarker of vulnerability for later PTA. Conversely, development and recovery from PTA appear to be facilitated by white and gray matter structural changes in a major hippocampal pathway, the fornix. The present findings shed new light on neuroanatomical substrates of recovery from PTA and characterize white matter biomarkers of risk for posttraumatic dysfunction. © 2020 Wiley Periodicals LLC.


    Nathaniel G Harnett, Jennifer S Stevens, Sanne J H van Rooij, Timothy D Ely, Vasiliki Michopoulos, Lauren Hudak, Tanja Jovanovic, Barbara O Rothbaum, Kerry J Ressler, Negar Fani. Multimodal structural neuroimaging markers of risk and recovery from posttrauma anhedonia: A prospective investigation. Depression and anxiety. 2021 Jan;38(1):79-88

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33169525

    View Full Text