Therapeutic strategies targeting FOXO transcription factors.

Giampaolo Calissi, Eric W-F Lam, Wolfgang Link

Nature reviews. Drug discovery 2021 Jan

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FOXO proteins are transcription factors that are involved in numerous physiological processes and in various pathological conditions, including cardiovascular disease, cancer, diabetes and chronic neurological diseases. For example, FOXO proteins are context-dependent tumour suppressors that are frequently inactivated in human cancers, and FOXO3 is the second most replicated gene associated with extreme human longevity. Therefore, pharmacological manipulation of FOXO proteins is a promising approach to developing therapeutics for cancer and for healthy ageing. In this Review, we overview the role of FOXO proteins in health and disease and discuss the pharmacological approaches to modulate FOXO function.

Citation

Giampaolo Calissi, Eric W-F Lam, Wolfgang Link. Therapeutic strategies targeting FOXO transcription factors. Nature reviews. Drug discovery. 2021 Jan;20(1):21-38