Research Progress on circRNA in Nervous System Diseases.

Nana Ma, Wei Zhang, Jun Wan

Current Alzheimer research 2020

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Circular RNAs (circRNAs) are a kind of non-coding RNA molecule with highly stable circular structures. CircRNAs are primarily composed of exons and/or introns. Recently, a lot of exciting studies showed that circRNA played an essential role in the development of nervous system diseases. Here, classification, characteristics, biogenesis, and the association of circRNA dysregulation with nervous system diseases, such as Alzheimer's disease, are summarized. The review not only contributes to a better understanding of circRNAs, but also provides new research directions toward the diagnosis, treatment, and prevention of nervous system diseases. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.