Eph Receptors in the Immunosuppressive Tumor Microenvironment.

Peter W Janes, Mary E Vail, Matthias Ernst, Andrew M Scott

Cancer research 2021 Feb 15

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The tumor microenvironment (TME) promotes tumor development via complex intercellular signaling, aiding tumor growth and suppressing immunity. Eph receptors (Eph) and their ephrin ligands control cell interactions during normal development, and reemerge in tumors and the TME, where they are implicated in invasion, metastasis, and angiogenesis. Recent studies also indicate roles for Ephs in suppressing immune responses by controlling tumor interactions with innate and adaptive immune cells within the TME. Accordingly, inhibiting these functions can promote immune response and efficacy of immune checkpoint inhibition. This research highlights Ephs as potential targets to enhance efficacy of immune-based therapies in patients with cancer. ©2020 American Association for Cancer Research.

Citation

Peter W Janes, Mary E Vail, Matthias Ernst, Andrew M Scott. Eph Receptors in the Immunosuppressive Tumor Microenvironment. Cancer research. 2021 Feb 15;81(4):801-805