Clinical characteristics of COVID-19 patients with asthma in Wuhan, China: a retrospective cohort study.

Although it is reported that patients with coronavirus disease 2019 (COVID-19) disease who have comorbidities are at higher risk to suffer adverse clinical outcomes, there are inadequate evidence to clarify the association between COVID-19 and asthma. On this ground, this study aims to systematically analyze the clinical characteristics of COVID-19 patients with asthma. In this single-center, retrospective and observational cohort study, 21 COVID-19 patients with asthma and 100 non-asthma COVID-19 patients were statistically matched by propensity score based on age, sex and comorbidities. Meanwhile, a collection and comparison concerning demographic indicators, clinical and laboratory examinations, treatments and outcomes were conducted between two groups to specify their differences. Statistically, the COVID-19 patients with asthma had a higher proportion of ICU admission (14.3% [3/21] vs. 2.1% [2/96] p = 0.040) than those who do not have. On top this, a higher level of inflammatory responses, such as interleukin 6, interleukin 8, procalcitonin, leukocytes, neutrophils and CD4+ T cells was presented in asthma patients. Moreover, the increase of organ damage indices like D-dimer, lactate dehydrogenase and high-sensitivity cardiac troponin I, were more pronounced in COVID-19 patients with asthma. Exacerbated inflammatory responses and multiple organ damages were triggered in COVID-19 patients with asthma, which highlights more intensive surveillance and supportive treatment.

Citation

Meng Jin, Can Chen, Jinyu Huang, Fengqin Zhang, Tianyi Dong, Ming Zhang, Huihui Yue, Kui Liu, Guangcai Li, Ke Hu, Huilan Zhang. Clinical characteristics of COVID-19 patients with asthma in Wuhan, China: a retrospective cohort study. The Journal of asthma : official journal of the Association for the Care of Asthma. 2022 Feb;59(2):230-238

Mesh Tags

Substances

PMID: 33183117

search → result