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    Due to the blooming development of nanotechnology, the further understanding of nanomaterials-induced toxicity has been demanded. Following their introduction into a biological matrix, the surface of nanoparticles (NPs) is covered by protein layer, namely corona, which imparts a new biological identity to NPs. Here, we showed that fibrinogen (Fg), but not albumin (BSA) or hemoglobin (Hb), decoration on the surface of silica nanoparticles (SiO2 NPs) ameliorate their pro-autophagic activity in non-phagocytic cells. Surprisingly, this effect of Fg was compromised in phagocytic cells. Further mechanistic investigation suggested coronal Fg has dual effects on the tuning of SiO2 NPs-induced autophagic response. First, Fg decoration blocks SiO2 NPs sedimentation through stabilize SiO2 NPs suspension; secondly, Fg coverage inhibits SiO2 NPs' cellular internalization. These findings provided important insights into the understanding of NPs-corona complexes behaviors and indicate future directions for the investigation of corona-mediated biological activities. Copyright © 2020 Elsevier B.V. All rights reserved.


    Lihui Zhang, Wei Wei, Zixuan Liu, Xuting Liu, Erqun Song, Yang Song. Dual effects of fibrinogen decoration on the tuning of silica nanoparticles-induced autophagic response: The implication of sedimentation and internalization. Journal of hazardous materials. 2021 Apr 15;408:124467

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    PMID: 33187794

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