Potential interference on the lipid metabolisms by serum copper in a women population: A repeated measurement study.

Junxi Chen, Changxin Lan, Hang An, Yu Jin, Qi Li, Shufang Ge, Yanxin Yu, Guofeng Shen, Bo Pan, Ying Xu, Rongwei Ye, Zhiwen Li, Bin Wang

The Science of the total environment 2021 Mar 15

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The relationship between excess copper (Cu) intake and lipid metabolic disorders is not well-studied, and most studies on this topic have a cross-sectional design. Here, we investigated the relationship between Cu exposure and blood lipid metabolism in women population, as well as potential mediation effects of oxidative stress and inflammation, using a repeated-measurement study. A total of 35 women in northern China were included, and each individual was visited for five times. Blood samples were collected, and the following serum biomarkers were analyzed: heme oxygenase-1 (HO-1), monocyte chemotactic protein-1 (MCP-1), interleukin (IL)-6, IL-8, and lipids [triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and lipoprotein(a) (Lp(a))]. A linear mixed-effect model was used to analyze the associations between Cu and the individual biomarkers in serum. The results showed that Cu was positively associated with TG (β = 0.0007, P = 0.01), TC (β = 0.0006, P = 0.002), LDL (β = 0.0004, P ≤ 0.001), and Lp(a) (β = 0.0004, P = 0.01), but not associated with HDL (β = 0.0001, P = 0.19). Likewise, serum Cu was positively associated with HO-1 (β = 0.0004, P = 0.03) and negatively associated with MCP-1 (β = -0.0006, P = 0.003) and IL-8 (β = -0.002, P = 0.03). Among the biomarkers of oxidative stress, inflammation, and lipids in serum, only IL-8 was negatively associated with HDL (β = -0.0004, P = 0.009). No other associations were observed. We conclude that high Cu exposure may elevate blood lipid levels as well as disturb processes related to oxidative stress and inflammation responses. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Junxi Chen, Changxin Lan, Hang An, Yu Jin, Qi Li, Shufang Ge, Yanxin Yu, Guofeng Shen, Bo Pan, Ying Xu, Rongwei Ye, Zhiwen Li, Bin Wang. Potential interference on the lipid metabolisms by serum copper in a women population: A repeated measurement study. The Science of the total environment. 2021 Mar 15;760:143375