Candida albicans steryl 6-O-acyl-α-D-mannosides agonize signalling through Mincle.

Tram Nguyen, Yuki Hosono, Takashi Shimizu, Sho Yamasaki, Spencer J Williams

Chemical communications (Cambridge, England) 2020 Dec 07

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The C-type lectin receptor Mincle binds Candida albicans and has been implicated in its pathobiology, but the molecular effectors responsible have not been identified. We report the synthesis of cholesteryl and ergosteryl 6-O-acyl-α-d-mannosides, produced by C. albicans mycelium, and demonstrate their ability to signal through human and mouse Mincle.

Citation

Tram Nguyen, Yuki Hosono, Takashi Shimizu, Sho Yamasaki, Spencer J Williams. Candida albicans steryl 6-O-acyl-α-D-mannosides agonize signalling through Mincle. Chemical communications (Cambridge, England). 2020 Dec 07;56(95):15060-15063