Thermosensitivity of the voltage-dependent activation of calcium homeostasis modulator 1 (calhm1) ion channel.

Young Keul Jeon, Si Won Choi, Jae Won Kwon, Joohan Woo, Seong Woo Choi, Sang Jeong Kim, Sung Joon Kim

Biochemical and biophysical research communications 2021 Jan 01

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Calcium homeostasis modulator 1 (calhm1) proteins form an outwardly rectifying nonselective ion channel having exceedingly slow kinetics and low sensitivity to voltage that is shifted by lowering extracellular Ca2+ ([Ca2+]e). Here we found that physiological temperature dramatically facilitates the voltage-dependent activation of the calhm1 current (Icalhm1); increased amplitude (Q10, 7-15) and fastened speed of activation. Also, the leftward shift of the half-activation voltage (V1/2) was similary observed in the normal and lower [Ca2+]e. Since calhm1 is highly expressed in the brain and taste cells, the thermosensitivity should be considered in their electrophysiology. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Young Keul Jeon, Si Won Choi, Jae Won Kwon, Joohan Woo, Seong Woo Choi, Sang Jeong Kim, Sung Joon Kim. Thermosensitivity of the voltage-dependent activation of calcium homeostasis modulator 1 (calhm1) ion channel. Biochemical and biophysical research communications. 2021 Jan 01;534:590-596