Efficacy of the AV7909 anthrax vaccine candidate in guinea pigs and nonhuman primates following two immunizations two weeks apart.

Jeffry D Shearer, Lisa Henning, Daniel C Sanford, Na Li, Mario H Skiadopoulos, Joshua J Reece, Boris Ionin, Vladimir Savransky

Vaccine 2021 Jan 03

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The anthrax vaccine candidate AV7909 is being developed as a next-generation vaccine for post-exposure prophylaxis (PEP) against inhalational anthrax. In clinical studies, two vaccinations with AV7909 administered either two or four weeks apart induced an enhanced immune response compared to BioThrax® (Anthrax Vaccine Adsorbed) (AVA). Anthrax toxin-neutralizing antibody (TNA) levels on Day 70 following initial vaccination that were associated with protection of animals exposed to inhalational anthrax were previously reported for the 0, 4-week AV7909 vaccination regimen. The current study shows that a 0, 2-week AV7909 vaccination regimen protected guinea pigs (GPs) and nonhuman primates (NHPs) against a lethal inhalational anthrax challenge on Days 28 and 70 after the first immunization. An earlier induction of protective TNA levels using a 0, 2-week AV7909 vaccination regimen may provide benefit over the currently approved AVA PEP 0, 2, and 4-week vaccination regimen. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Citation

Jeffry D Shearer, Lisa Henning, Daniel C Sanford, Na Li, Mario H Skiadopoulos, Joshua J Reece, Boris Ionin, Vladimir Savransky. Efficacy of the AV7909 anthrax vaccine candidate in guinea pigs and nonhuman primates following two immunizations two weeks apart. Vaccine. 2021 Jan 03;39(1):1-5