Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in Cutibacterium acnes (formerly Propionibacterium acnes), a human skin commensal bacterium that is widely distributed across individuals and skin sites. Experimental characterization of this biosynthetic gene cluster resulted in identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles revealed that cutimycin contributed to the ecology of the skin hair follicle microbiota and helped to reduce colonization of skin hair follicles by Staphylococcus species. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.


Jan Claesen, Jennifer B Spagnolo, Stephany Flores Ramos, Kenji L Kurita, Allyson L Byrd, Alexander A Aksenov, Alexey V Melnik, Weng R Wong, Shuo Wang, Ryan D Hernandez, Mohamed S Donia, Pieter C Dorrestein, Heidi H Kong, Julia A Segre, Roger G Linington, Michael A Fischbach, Katherine P Lemon. A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles. Science translational medicine. 2020 Nov 18;12(570)

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 33208503

View Full Text