Effects of antihyperglycemics on endothelial progenitor cells].

Xue Han, Guojun Jiang, Qiaojuan Shi

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2020 Oct 25

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Endothelial progenitor cells (EPCs) play an important role in diabetic vascular complications. A large number of studies have revealed that some clinical antihyperglycemics can improve the complications of diabetes by regulating the function of EPCs. Metformin can improve EPCs function in diabetic patients by regulating oxidative stress level or downstream signaling pathway of adenosine monophosphate activated protein kinase; Pioglitazone can delay the aging of EPCs by regulating telomerase activity; acarbose, sitagliptin and insulin can promote the proliferation, migration and adhesion of EPCs. In addition to lowering blood glucose, the effects of antihyperglycemics on EPCs may also be one of the mechanisms to improve the complications of diabetes. This article reviews the research progress on the regulation of EPC proliferation and function by antihyperglycemics.

Citation

Xue Han, Guojun Jiang, Qiaojuan Shi. Effects of antihyperglycemics on endothelial progenitor cells]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2020 Oct 25;49(5):629-636