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Cryotherapy is an ablation modality relying on freeze-thaw cycles to promote cell death through intracellular ice crystal formation, ischemia, and apoptosis. Currently, 2 different cryotherapy systems are available for esophageal use. The first is cryospray ablation, which involves repetitive applications of liquid nitrogen. The second system, cryoballoon ablation, freezes the esophageal mucosa with liquid nitrous oxide using a compliant balloon. To date, studies have shown that cryotherapy is an effective and safe method for eradicating Barrett's esophagus; however, larger prospective series with longer follow-up are warranted to determine the clinical utility of cryotherapy in the treatment of Barrett's esophagus. Copyright © 2020 Elsevier Inc. All rights reserved.


Charlotte N Frederiks, Marcia Irene Canto, Bas L A M Weusten. Updates in Cryotherapy for Barrett's Esophagus. Gastrointestinal endoscopy clinics of North America. 2021 Jan;31(1):155-170

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PMID: 33213793

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