Correlation Engine 2.0
Clear Search sequence regions


  • allele (1)
  • cba mice (2)
  • cohorts (1)
  • diagnosis (1)
  • gene (1)
  • humans (1)
  • leukemia (2)
  • linear- model (2)
  • mice (3)
  • myeloid leukemia (7)
  • number cells (1)
  • Sfpi1 (3)
  • survivors (1)
  • Sizes of these terms reflect their relevance to your search.

    The effect of low-dose ionizing radiation exposure on leukemia incidence remains poorly understood. Possible dose-response curves for various forms of leukemia are largely based on cohorts of atomic bomb survivors. Animal studies can contribute to an improved understanding of radiation-induced acute myeloid leukemia (rAML) in humans. In male CBA/H mice, incidence of rAML can be described by a two-hit model involving a radiation-induced deletion with Sfpi1 gene copy loss and a point mutation in the remaining Sfpi1 allele. In the present study (historical) mouse data were used and these processes were translated into a mathematical model to study photon-induced low-dose AML incidence in male CBA/H mice following acute exposure. Numerical model solutions for low-dose rAML incidence and diagnosis times could respectively be approximated with a model linear-quadratic in radiation dose and a normal cumulative distribution function. Interestingly, the low-dose incidence was found to be proportional to the modeled number of cells carrying the Sfpi1 deletion present per mouse following exposure. After making only model-derived high-dose rAML estimates available to extrapolate from, the linear-quadratic model could be used to approximate low-dose rAML incidence calculated with our mouse model. The accuracy in estimating low-dose rAML incidence when extrapolating from a linear model using a low-dose effectiveness factor was found to depend on whether a data transformation was used in the curve fitting procedure.

    Citation

    Sjors Stouten, Sjoerd Verduyn Lunel, Rosemary Finnon, Christophe Badie, Fieke Dekkers. Modeling low-dose radiation-induced acute myeloid leukemia in male CBA/H mice. Radiation and environmental biophysics. 2021 Mar;60(1):49-60


    PMID: 33221961

    View Full Text