Update on Calcitonin Gene-Related Peptide Antagonism in the Treatment of Migraine.

Edoardo Caronna, Amaal J Starling

Neurologic clinics 2021 Feb

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The discovery of calcitonin gene-related peptide (CGRP) and its role in migraine has promoted a new era in migraine treatment: CGRP antagonism. Two classes of medications are currently available: small molecules targeting the CGRP receptor and monoclonal antibodies targeting the CGRP receptor or CGRP ligand. The revolution of these medications is represented by blurring the borders between acute and preventive treatments, episodic and chronic migraine, naïve and refractory patients and even between migraine and other headache disorders. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Edoardo Caronna, Amaal J Starling. Update on Calcitonin Gene-Related Peptide Antagonism in the Treatment of Migraine. Neurologic clinics. 2021 Feb;39(1):1-19