Correlation Engine 2.0
Clear Search sequence regions

  • cyanobacteria (2)
  • factor (4)
  • gene (2)
  • genomes (1)
  • σ factors (7)
  • Sizes of these terms reflect their relevance to your search.

    Sigma (σ) factors are key regulatory proteins that control the transcription initiation in prokaryotes. In response to environmental or developmental cues, σ factors initiate the transcription of necessary genes responsible for maintaining a life-sustaining metabolic balance. Due to the significant role of σ factors in bacterial metabolism, their rational engineering for commercial metabolite production in photoautotrophic, cyanobacterial cells is a desirable venture. As cyanobacterial genomes typically encode multiple σ factors, effective execution of metabolic engineering efforts largely relies on uncovering the complicated gene regulatory network and further characterization of the members of σ factor regulatory circuits. This review outlines the prospects of σ factor in metabolic engineering of cyanobacteria, summarizes the challenges in the path towards an efficient strain construction and highlights the genomic context of putative regulators of cyanobacterial σ factors. Copyright © 2020 Elsevier Ltd. All rights reserved.


    Amit Srivastava, Rajeev K Varshney, Pratyoosh Shukla. Sigma Factor Modulation for Cyanobacterial Metabolic Engineering. Trends in microbiology. 2021 Mar;29(3):266-277

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33229204

    View Full Text