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RSK2 and ERα comrades-in-arms in homeostasis and transformation.
Molecular & cellular oncology 2020 Nov 01Sizes of these terms reflect their relevance to your search.
The physiological response to estrogen differs according to the developmental stage. We show, in the adult, estrogen-responsiveness is driven by ERK1/2 (extracellular signal-regulated kinase 1/2) whereas its downstream effector, RSK2 (p90 ribosomal S6 kinase 2), prevents continuous ERK1/2 activity through regulation of oxidative stress. Bioinformatic analysis revealed RSK2 association with breast cancer risk and oral contraceptives. © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
Citation
Katarzyna A Ludwik, Deborah A Lannigan. RSK2 and ERα comrades-in-arms in homeostasis and transformation. Molecular & cellular oncology. 2020 Nov 01;7(6):1825916
PMID: 33235919
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