Anti-IL-5 in pediatric allergic diseases.

Laura Tenero, Elisa Arturi, Michele Piazza, Giorgio Piacentini

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2020 Nov

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Interleukin (IL)-5 is a potent mediator of the inflammatory cascade in the allergic response. Its predominant role in atopic reactions makes this cytokine an ideal target for blocking the eosinophilic inflammatory hyper-responsiveness to allergens. The management of allergic diseases in childhood-such as severe asthma, atopic dermatitis, and eosinophilic esophagitis-is a challenge. In particular, there are concerns regarding the use of high-dose corticosteroids. Over the last few years, biologics targeting IL-5 or IL-5 receptor-that are mepolizumab, reslizumab, and benralizumab-represent a new, promising, and more personalized therapeutic option. © 2020 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

Citation

Laura Tenero, Elisa Arturi, Michele Piazza, Giorgio Piacentini. Anti-IL-5 in pediatric allergic diseases. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2020 Nov;31 Suppl 26:14-16