Association between MMP16 rs60298754 and clinical phenotypes of Parkinson's disease in southern Chinese.

The aim was to investigate the association between MMP16 rs60298754 and symptoms of Parkinson's disease (PD) in southern Chinese. Seven hundred forty-five PD patients were recruited in this study. All patients were evaluated by Brief Pain Inventory (BPI), Hamilton anxiety rating scale and Hamilton depression rating scale, 39-item Parkinson's disease Questionnaire (PDQ-39), and MDS-Unified PD Rating Scale (MDS-UPDRS). Symptoms were also recorded. The difference of BPI and Parkinson's disease sleep scale (PDSS) between two groups was showed (BPI: MMP16 wildtypes: 14.73 ± 14.45; MMP16 carriers: 10.95 ± 10.67, p 0.002; PDSS: MMP16 wildtypes: 117.80 ± 21.45; MMP16 carriers: 108.40 ± 23.95, p < 0.001). The association of apathy, nocturia, and sensitive to light were found (apathy: p 0.001, OR: 0.49, 0.32-0.76; nocturia: p < 0.001, OR: 3.57, 1.90-7.26; sensitive to light: p < 0.001, OR: 3.99, 2.01-7.74). MMP16 rs60298754 was associated with the presence of apathy, pain, nocturia, and sensitive to light. © 2020. Fondazione Società Italiana di Neurologia.

Citation

Kui Chen, Meng-Ruo Guo, Yue Zhang, Gang Li, Yi Liu, Bei Zhang. Association between MMP16 rs60298754 and clinical phenotypes of Parkinson's disease in southern Chinese. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2021 Aug;42(8):3211-3215

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PMID: 33241532

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