cGAS-STING signaling in cancer immunity and immunotherapy.

Huashan Du, Tianmin Xu, Manhua Cui

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan

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Recent studies have shown that the innate immune cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway may play an important role in antitumor immunity. Additionally, the cGAS-STING pathway promotes the senescence of cancer cells, induces apoptosis of cancer cells, and increases the protective effect of cytotoxic T cells and natural killer cell-mediated cytotoxicity. We believe that the combination of the cGAS-STING signaling pathway with other therapeutic methods provides a new perspective from which to overcome obstacles in the application of this review. Further, we highlight the antitumor mechanism of the cGAS-STING signaling pathway and the latest advances in monotherapy and combination therapy with related agonists. Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Citation

Huashan Du, Tianmin Xu, Manhua Cui. cGAS-STING signaling in cancer immunity and immunotherapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jan;133:110972