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The success of artificial vascular graft in the host to obtain functional tissue regeneration and remodeling is a great challenge in the field of small diameter tissue engineering blood vessels. In our previous work, poly(ε-caprolactone) (PCL)/fibrin vascular grafts were fabricated by electrospinning. It was proved that the PCL/fibrin vascular graft was a suitable small diameter tissue engineering vascular scaffold with good biomechanical properties and cell compatibility. Here we mainly examined the performance of PCL/fibrin vascular graft in vivo. The graft showed randomly arranged nanofiber structure, excellent mechanical strength, higher compliance and degradation properties. At 9 months after implantation in the rat abdominal aorta, the graft induced the regeneration of neoarteries, and promoted ECM deposition and rapid endothelialization. More importantly, the PCL/fibrin vascular graft showed more microvessels density and fewer calcification areas at 3 months, which was beneficial to improve cell infiltration and proliferation. Moreover, the ratio of M2/M1macrophage in PCL/fibrin graft had a higher expression level and the secretion amount of pro-inflammatory cytokines started to increase, and then decreased to similar to the native artery. Thus, the electrospun PCL/fibrin tubular vascular graft had great potential to become a new type of artificial blood vessel scaffold that can be implanted in vivo for long term. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Liang Zhao, Xiafei Li, Lei Yang, Lulu Sun, Songfeng Mu, Haibin Zong, Qiong Li, Fengyao Wang, Shuang Song, Chengqiang Yang, Changhong Zhao, Hongli Chen, Rui Zhang, Shicheng Wang, Yuzhen Dong, Qiqing Zhang. Evaluation of remodeling and regeneration of electrospun PCL/fibrin vascular grafts in vivo. Materials science & engineering. C, Materials for biological applications. 2021 Jan;118:111441

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PMID: 33255034

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