Correlation Engine 2.0
Clear Search sequence regions

  • dimer (1)
  • DOX (3)
  • doxorubicin (2)
  • drug carriers (4)
  • dye (12)
  • heat (4)
  • hyperthermia (1)
  • mice (2)
  • near (4)
  • redox (1)
  • tumor site (1)
  • Sizes of these terms reflect their relevance to your search.

    Near-infrared (NIR)-induced dye-based theranostic drug delivery carriers are used for critical image-guided chemo-photothermal cancer therapy. However, most carriers fail to deliver sufficient heat and fluorescence efficiently due to direct π-π stacking of the aromatic rings of the NIR dye and drug. In the work reported herein, we examined a self-assembled heptamethine cyanine dye dimer (CyD) with improved heat and fluorescence delivery that was developed by manipulating the unique structural and optical properties of the dimer. The H-aggregation of CyD in an aqueous solution generated a great amount of heat by transforming the energy of the excited electrons into non-radiative energy. Moreover, the disulfide bond of CyD assisted nanoparticles with a drug by minimizing the interaction between the NIR dye and drug, and also by releasing the drug in a redox environment. As a result, DOX encapsulated within CyD (CyD/DOX) showed strong heat generation and fluorescence imaging in tumor-bearing mice, allowing detection of the tumor site and inhibition of tumor growth by chemo-photothermal therapy. The multiplicity of features supplied by the newly developed CyD demonstrated the potential of CyD/DOX as an NIR dye-based theranostic drug-delivery carrier for effective chemo-photothermal cancer therapy. Copyright © 2020 Elsevier B.V. All rights reserved.


    Chanuk Jeong, Saji Uthaman, Babak Bagheri, Juwhan Kim, Shameer Pillarisetti, In-Kyu Park, Yeu-Chun Kim. Self-assembled heptamethine cyanine dye dimer as a novel theranostic drug delivery carrier for effective image-guided chemo-photothermal cancer therapy. Journal of controlled release : official journal of the Controlled Release Society. 2021 Jan 10;329:50-62

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33259849

    View Full Text