Recent advance of spleen tyrosine kinase in diseases and drugs.

Yuxin Shao, Su Zhang, Yanfen Zhang, Zhongcheng Liu

International immunopharmacology 2021 Jan

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Spleen tyrosine kinase (Syk) is a non-receptor protein tyrosine kinase, also known as p72Syk. It is important for downstream signaling from cell surface receptors, such as Fc receptors, complement receptors and integrin. Syk plays the critical role in triggering immune and allergic reactions, the signaling pathway of Syk has become the research focus on drugs for allergic disease and human malignancies. This review summarized the characteristics of Syk, its mechanism in related reactions, and mainly discussed the signal transduction pathway mediated by Syk. With the development of industry and the aggravation of environmental pollution, the incidence of allergic diseases is increasing, it has become a global priority disease. In this process, Syk participates in IgE/FcεRI signaling pathway plays a critical role in triggering allergic reactions. This review described the characteristics and the interaction mechanism of Syk and its binding proteins in disease, and summarized the research status of targeted Syk inhibitors. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Yuxin Shao, Su Zhang, Yanfen Zhang, Zhongcheng Liu. Recent advance of spleen tyrosine kinase in diseases and drugs. International immunopharmacology. 2021 Jan;90:107168