TGF-β Pathway in Salivary Gland Fibrosis.

Xianglan Zhang, Jun Seop Yun, Dawool Han, Jong In Yook, Hyun Sil Kim, Eunae Sandra Cho

International journal of molecular sciences 2020 Nov 30

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Fibrosis is presented in various physiologic and pathologic conditions of the salivary gland. Transforming growth factor beta (TGF-β) pathway has a pivotal role in the pathogenesis of fibrosis in several organs, including the salivary glands. Among the TGF-β superfamily members, TGF-β1 and 2 are pro-fibrotic ligands, whereas TGF-β3 and some bone morphogenetic proteins (BMPs) are anti-fibrotic ligands. TGF-β1 is thought to be associated with the pro-fibrotic pathogenesis of sialadenitis, post-radiation salivary gland dysfunction, and Sjögren's syndrome. Potential therapeutic strategies that target multiple levels in the TGF-β pathway are under preclinical and clinical research for fibrosis. Despite the anti-fibrotic effect of BMPs, their in vivo delivery poses a challenge in terms of adequate clinical efficacy. In this article, we will review the relevance of TGF-β signaling in salivary gland fibrosis and advances of potential therapeutic options in the field.

Citation

Xianglan Zhang, Jun Seop Yun, Dawool Han, Jong In Yook, Hyun Sil Kim, Eunae Sandra Cho. TGF-β Pathway in Salivary Gland Fibrosis. International journal of molecular sciences. 2020 Nov 30;21(23)