Drug eluting implants in pharmaceutical development and clinical practice.

Ashley R Johnson, Seth P Forster, David White, Graciela Terife, Michael Lowinger, Ryan S Teller, Stephanie E Barrett

Expert opinion on drug delivery 2021 May

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Introduction: Drug eluting implants offer patient convenience and improved compliance through less frequent dosing, eliminating repeated, painful injections and providing localized, site specific delivery with applications in contraception, ophthalmology, and oncology.Areas covered: This review provides an overview of available implant products, design approaches, biodegradable and non-biodegradable polymeric materials, and fabrication techniques with a focus on commercial applications and industrial drug product development. Developing trends in the field, including expanded availability of suitable excipients, development of novel materials, scaled down manufacturing process, and a wider understanding of the implant development process are discussed and point to opportunities for differentiated drug eluting implant products.Expert opinion: In the future, long-acting implants will be important clinical tools for prophylaxis and treatment of global health challenges, especially for infectious diseases, to reduce the cost and difficulty of treating chronic indications, and to prolong local delivery in difficult to administer parts of the body. These products will help improve patient safety, adherence, and comfort.

Citation

Ashley R Johnson, Seth P Forster, David White, Graciela Terife, Michael Lowinger, Ryan S Teller, Stephanie E Barrett. Drug eluting implants in pharmaceutical development and clinical practice. Expert opinion on drug delivery. 2021 May;18(5):577-593