PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin.

European journal of immunology 2021 Mar

filter terms:

A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA-I research in the fields of oncology, infectiology, and autoimmunity. © 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.

Citation

Antonius A de Waard, Tamara Verkerk, Marlieke L M Jongsma, Kelly Hoefakker, Sunesh Sethumadhavan, Carolin Gerke, Sophie Bliss, Xiangrui Kong, George M C Janssen, Arnoud H de Ru, Frans H J Claas, Arend Mulder, Robert Tampé, Peter A van Veelen, Anne Halenius, Robbert M Spaapen. PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin. European journal of immunology. 2021 Mar;51(3):734-737